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for the Swiss 3RCC 3rs Day 2024 taking place in Zurich hosted by the University of Zurich & the ETH Zurich.

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Second 3Rs Day by i3s in Porto, Portugal (and online) on "Models in Biomedical Research". Find more info here: https://www.i3s.up.pt/event.php?v=327

Don't miss the presentation on rodent MDA by Dr. Paulin Jirkof

By: Dr. Paulin Jirkof (University of Zurich).

Date: September 10, 2024, Helsinki 2 PM EEST

ABSTRACT:

In drug development, a focus on oral formulations aligns with human treatment practices. Preclinical assessments demand crucial oral testing of compounds, often carried out through oral gavage in mice and rats. However, this widely used method lacks accuracy in replicating voluntary substance intake of humans, posing risks of injury and stress to laboratory rodents. This presentation scrutinizes the pros and cons of oral gavage and explores alternative approaches, including uncontrolled oral intake (e.g., via drinking water), and refined, controlled voluntary ingestion protocols. The Micropipette-Guided Drug Administration (MDA) method, employing palatable solutions like sweetened condensed milk diluted with water, will be introduced. The talk will evaluate evidence on the suitability of these alternative methods for administering various experimental substances, such as analgesics, tamoxifen or others, while prioritizing animal welfare.

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Karolinska Institutet presents: Webinar with Dr. Paulin Jirkof

Learn more about the pros and cons of oral gavage and explores alternative approaches, including injections, uncontrolled oral intake (e.g., via drinking water), and refined, controlled voluntary ingestion protocols. The Micropipette-Guided Drug Administration (MDA) method, employing palatable solutions like sweetened condensed milk diluted with water, will be introduced. The talk will evaluate evidence on the suitability of these alternative methods for administering various experimental substances, such as analgesics, tamoxifen or others, while prioritizing animal welfare.

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Speaker

Dr. Paulin Jirkof works as the 3R at the University of Zurich's Office for Animal Welfare and 3R. She also chairs the Executive Board of the Swiss 3R Competence Center, is a board member of the Swiss Society for Laboratory Animal Science, and serves as Editor-in-Chief of the journal Laboratory Animal. Her research primarily focuses on refining laboratory rodent practices, with a particular emphasis on assessing and improving animal welfare.

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