These slides provide essential information on Micropipette-guided Drug Administration (MDA) in rodents, equipping you with the knowledge needed to apply this technique in your current or future research. Also, feel free to use this video as teaching material for your students.
What is Rodent MDA? Why should you choose Rodent MDA over oral gavage? How to do Rodent MDA? These questions will be answered in this introductory video. Watch and share! MDA stands for "Micropipette-guided Drug Administration". MDA is a 3R-refinement method for oral drug administration and as such, minimizes stress and harm to lab animals and increases their welfare.
To recognize his outstanding contribution to the promotion of the 3Rs principle, the Swiss 3RCC presented its 2020 Young 3Rs Investigator Award to PhD student Joseph Scarborough for his work in Prof. Urs Meyer’s laboratory at the Institute of Veterinary Pharmacology and Toxicology at the University of Zurich. Scarborough developed a novel method (MDA) to administer pharmaceutical substances to mice with a sweetened solution using a small pipette, thus motivating the animals to voluntarily take the pharmaceutical substances. This MDA method development was awarded for its reduction of the animals' stress, for improving their welfare, and therefore also for the quality of study results. In this video, Prof Urs Meyer explains the method, its benefits, and its impact on refinement.
Team Rodent MDA
University of Zurich
rodentmda@uzh.ch